�VaxInnate Corporation announced that its M2e universal flu vaccine candidate was good and immunogenic in its first Phase I clinical trial, fosterage hopes for a universal influenza vaccine that could provide protection against seasonal worker and pandemic influenza strains.
"We'd characterise VaxInnate's M2e universal grippe vaccine campaigner as very promising, based upon the immune responses and tolerability we saw in the clinical trial participants," said Christine Turley, MD, Director of clinical trials and clinical research at the Sealy Center for Vaccine Development, University of Texas Medical Branch (UTMB), and the study's primary investigator. "UTMB is committed to further studies of VaxInnate's vaccine candidate, which has the potential to be a safe, highly effective and much-needed option to prevent seasonal and pandemic influenza A."
The trial is a milestone for both the vaccine candidate and for VaxInnate, according to CEO Alan Shaw, PhD.
"We're very pleased with the study data, which march that VaxInnate's M2e universal flu vaccinum candidate is safe and capable of eliciting a more potent immune answer by delivering a 'one-two punch' that triggers both arms of the body's immune defense," Dr. Shaw said. "Furthermore, it accomplishes this at doses below a microgram of vaccinum antigen and without the use of conventional adjuvants. In little, this vaccine candidate has passed a critical initial test with data that have exceeded our expectations."
The results of the study will be presented at the joint Interscience Conference on Antimicrobial Agents and Chemotherapy/Infectious Diseases Society of America (ICAAC/IDSA) meeting in October. UTMB and VaxInnate researchers are likewise collaborating on a holograph for submission to a peer-reviewed journal. To avoid jeopardizing the presentation and publication of the clinical data, further details of the study are not being disclosed at this time.
Sixty healthy pres Young adults participated in the double-blind, dose-escalating Phase I study, which was intentional to assess the safety and immunogenicity -- a patient's ability to generate an immune response -- of the M2e universal influenza vaccinum candidate in dosages of 0.3, 1, 3 and 10 ug injected 28 years apart.
The trial was also intentional to assess VaxInnate's approach to development and producing flu vaccines, which is based upon a proprietorship combination of toll-like receptor-mediated immune enhancement and recombinant bacterial production of vaccine antigen. This proprietary engineering could significantly reduce the time required to create vaccine supplies sufficient to meet national and even global necessarily.
VaxInnate's use of bacterial expression for production of influenza vaccines does non require dear expansion of manufacturing capacity, as do other influenza vaccine products. Due to its efficiency and transferability, VaxInnate's influenza vaccine could instead be produced in existing biotechnology facilities that have microbic production capacity.
No other vaccine applied science in enjoyment or in development today has these same potential capabilities.
The study was supported by a $9.5 gazillion grant awarded to UTMB by the Bill & Melinda Gates Foundation, for better control of grippe epidemics in the developing world.
VaxInnate's Approach and the M2e Universal Vaccine Candidate
A universal grippe vaccine would provide tribute against all strains of seasonal and pandemic flu A without needing to be renewed annually. While universal inoculation has been proposed to improve inoculation coverage and prevent disease, there ar no universal vaccines at this meter. Nor is there a means of developing and producing the volume of vaccine necessary to follow through universal influenza vaccine recommendations.
VaxInnate's universal influenza vaccinum candidate is designed to target the ectodomain of the M2 protein (M2e), an ion channel protein found on the surface of flu A viruses. M2e is the to the highest degree highly conserved surface protein of the virus, thereby eliminating the need for epidemiologists to identify and predict mental strain variants that emerge from year to year, as they mustiness now.
In developing traditional vaccines, epidemiologists must bode months in advance which flu strains will be circulating during the following fall and winter season in order to formulate a vaccine that targets the likeliest candidates. The selected strains are then manufactured in live, fertilized chicken egg using a laborious process that takes 6 to 9 months.
Federally-funded alternative approaches that are now in development, such as cell-based production, also take 6 months and would require large, committed manufacturing facilities.
Using egg- or even cell-based means, the time necessary to bring out flu vaccine today would make it difficult to respond to public health emergencies, such as the emergence of a pandemic flu, and impossible to reformulate vaccine if circulating strains do not rival those in the vaccinum, as was the case during the most late 2007-2008 grippe season.
Unlike technology that uses egg or cells for vaccinum production, VaxInnate's technology is based upon the formula in recombinant bacteria of relevant flu virus protein antigens amalgamate to the bacterial protein flagellin. Flagellin interacts with the immune system's toll-like receptors (TLRs), which part in human immune cells as sentries that detect pathogens and mount a general immune defense. This initial defensive structure releases cytokines and early signals that in become stimulate a second, stronger adaptive immune response, including production of pathogen-specific antibodies. VaxInnate scientists believe their technology will produce influenza vaccine of heretofore spiritual world quality that can be rapidly and inexpensively produced in volumes sufficient to achieve universal vaccination.
About VaxInnate
VaxInnate is a privately-held biotechnology company in Cranbury, NJ and New Haven, CT that is pioneering breakthrough technology for use in developing novel, proprietary vaccines for seasonal worker and pandemic influenza. This novel technology has the potential to dramatically amend the potentiality, manufacturing capacity and cost-effectiveness of influenza vaccines.
In addition to the M2e universal vaccinum candidate in clinical development, clinical trials for hemagglutinin (HA)-based seasonal and pandemic influenza vaccine candidates will begin this year.
VaxInnate's technology weapons platform is besides being investigated for development of vaccines for other diseases.
VaxInnate
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Wednesday, 10 September 2008
Sunday, 31 August 2008
X-Factor Contestant Accuses Producers Of Exploiting Teenage Suicides
Alexandra Davies, a contestant in the new series of X-Factor, has accused the shows producers of exploiting a recent freshet of suicides in her home town.
Davies said she was manipulated in to talking more or less the tragic run of deaths in Bridgend, which currently stands at 23, during her interview on the first step episode.
Davies, wHO was put through to the boot camp stages by judges, aforementioned in her interview: "Because of all the high-risk press that Bridgend has had late I just think chapeau getting through would be a beneficial bit of news that we motivation.
"Today is a big deal. This is where my confidence needs to deliver and I can prove to myself that I can buoy do this."
But she now claims she was encouraged to talk about the subject field against her wishes and has denied that she was quest sympathy.
�They thought that up when I said I was from Bridgend. The producers cherished me to talk well-nigh it merely I didn�t want to, just in case I offended someone�s family,� she told the Telegraph.
"I would often rather be known for the gift than the girl that comes from the suicide town. I didn�t live I was going to be on television and didn�t think I would be on as a lot as I was."
A spokesperson for X-Factor denied that the programme measuredly focussed on the suicides and aforesaid �absolutely no pressure placed on Alexandra during filming nor did she, or her parents, raise any concerns about her interview."
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Thursday, 21 August 2008
Mp3 music: Incognito
 Artist: Incognito: mp3 download Genre(s): Rock Rock: Pop-Rock funk Incognito's discography:  Who Needs Love Year: 2003 Tracks: 11  Love X Love Who Needs Love Remixes Year: 2003 Tracks: 11  Best of Incognito Year: 2000 Tracks: 13  No Time Like the Future Year: 1999 Tracks: 10  Beneath the Surface Year: 1997 Tracks: 12  100 Degrees and Rising Year: 1995 Tracks: 13  100 and Rising Year: 1995 Tracks: 13  Positivity Year: 1993 Tracks: 14  Tribes, Vibes and Scribes Year: 1992 Tracks: 11  Tribes Vibes + Scribes Year: 1992 Tracks: 11  Inside Life Year: 1992 Tracks: 12  Jazz Funk Year: 1981 Tracks: 11  Adventures In Black Sunshine Year: Tracks: 14 An acid jazz project with astonishingly bass roots in the seventies jazz/funk/fusion domain, Incognito was in the offset place formed by Jean-Paul Maunick (aka Bluey) and Paul "Tubbs" Williams. Both were leadership of the late-'70s disco-funk group Light of the World, wHO scored several moderate British hits, including a deal of "I Shot the Sheriff." Just later on the release of Light of the World's third gear LP (Check Us Out), Maunick and Williams shifted the card slightly and renamed the congeries Incognito. Incognito debuted with the individual "Parisienne Girl" and released the 1981 LP Jazz Funk, merely was nonoperational during the reside of the 1980s. Maunick continued to publish corporeal for his grouping, even patch working with Maxi Priest and others. (William Carlos Williams later moved to Finland.) By the beginning of the nineties, DJ fable and early Incognito fan Gilles Peterson had founded the Talkin' Loud label and he made Incognito one of his get-go signings. The 1991 single "Incessantly There" (with vocals by Jocelyn Brown) became a Top Ten hit as part of Britain's prospering acid jazz scene, suggestion the release of Incognito's second album overall, Inside Life. It was for the most part a studio involvement, with Maunick and technologist Simon Cotsworth guiding a big mold with many of the charles Herbert Best musicians in Britain's fertile groove residential area. With 1992's Tribes Vibes + Scribes, Maunick added a more than conventional singer, the American Maysa Leak. A cover of Stevie Wonder's "Don't You Worry 'Bout a Thing" became some other Incognito hit, and the album ascended Britain's pop charts even as it blush wine on America's contemporary jazz charts. The third album, Positivity, became the group's biggest album success, with much attention across Europe as well as Britain. Leak unsuccessfully attempted a solo life history with Blue Note, leading to the impermanent outspoken replacement Pamela Anderson (non the Baywatch pinup) on 1995's 100° and Rising. Leak returned, though, appearance on the following year's Beneath the Surface. Incognito later expanded its discography with 1996's Remixed, 1998's Tokyo Live, and 1999's No Time Like the Future. The group's following 2 albums were again made without Leak, 2001's Biography Stranger Than Fiction and 2003's World Health Organization Needs Love, which featured Brazilian singer Ed Motta. Leak returned for 2004's Adventures in Black Sunshine. Bees + Flowers + Things appeared at the ending of 2006. The album was a coalesce of cover versions along with re-recordings of iV Incognito classics. |
Monday, 11 August 2008
Lily Allen flashes her boobs twice
London (ANI): Lily Allen is the latest star to join the line of celebrities who revealed a little too much than expected. Visiting ex-boyfriend Ed Simons'' house in London, Allen made a major dummy show when one of her assets popped out of her clothes as she got out of her car.
In fact, the vocaliser gave a cheeky peek of her breasts, even when she walked towards his door, reports The Sun. The malfunction is assumed to be caused due to a lowest minute entanglement with the seat rap, with reports even calling it a deliberate attempt to establish off her assets. In fact, Lily gave retake of the breast show later, this time of the former one, on her fashion back home.
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In fact, the vocaliser gave a cheeky peek of her breasts, even when she walked towards his door, reports The Sun. The malfunction is assumed to be caused due to a lowest minute entanglement with the seat rap, with reports even calling it a deliberate attempt to establish off her assets. In fact, Lily gave retake of the breast show later, this time of the former one, on her fashion back home.
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Wednesday, 6 August 2008
Thursday, 19 June 2008
Talent shines in Season 6 debut of Canadian Idol
Here we go again with the sixth season of Canadian Idol.
With the promise from insiders that this is going to be the best group of talent yet, the premiere last night did have a few diamonds to offer.
The episode last night began with the audition tour stop in Toronto. Meet Omar Lunan, a 29-year-old single father from Scarborough whose smooth voice and cool vibe made the judges fall in love with him. So he�s got a gold ticket to the next round of the singing competition in Toronto.
Next was Tetiana Ostapowych, 25, who left Los Angeles to try out for Idol. With a gold ticket in her hand, her return to Canada paid off � for now.
The super-hyper Energizer Bunny was 29-year-old Gary Sneddon, who couldn�t hold a note or stand still. He got the boot.
But strange isn�t always that bad � at least not for Peterborough�s Taylor Abrahmse, 16, who after an odd take on Queen�s Tie Your Mother Down, was also moving on in the competition.
Then there were the Pigott brothers, Oliver, 27, and Sebastian, 25. The older of the two was living in the United Kingdom, but like many others, Idol is bringing him back.
Oliver has charisma. And if that isn�t enough his sweet, melodic voice and velvet tone are remarkable. Sebastian has a deep, sultry raspy voice and a cool but wacky personality that pulls you in for more. And they�re both sticking around.
Next stop was Calgary, where viewers were treated to more memorable performances like Jesse Cottam, 23, whose stellar voice earned him to a gold ticket.
A unique voice did the same for Earl Stevenson, 23, from Lloydminster, Alta., and for Theo Tams, 22, from Lethbridge, Alta., whose sweaty armpit stains and wicked performance of Howie Day�s Collide impressed the judges enough to give him a gold ticket.
Catch Canadian Idol again Monday on CTV at 9 p.m.
See Also
Wednesday, 11 June 2008
Mortician
Artist: Mortician
Genre(s):
Rock: Grindcore
Metal: Death,Black
Rock
Discography:
Re-Animated Dead Flesh
Year: 2004
Tracks: 22
Mortal Massacre
Year: 2004
Tracks: 17
Darkest Day of Horror
Year: 2003
Tracks: 20
Final Bloodbath Session
Year: 2002
Tracks: 28
Domain of Death
Year: 2001
Tracks: 17
Chainsaw Dismemberment
Year: 1999
Tracks: 28
Zombie Apocalypse
Year: 1998
Tracks: 10
Hacked Up for Barbecue
Year: 1996
Tracks: 24
House by the Cemetery
Year: 1995
Tracks: 10
A grindcore-influenced death-metal duo from Yonkers, NY, Mortician is made up of vocalist/bassist Will Rahmer and guitarist/drum machine computer programmer Roger Beaujard. Although the group's sound is extreme and inaccessible to many ears, their song intros and use of slasher-film samples demonstrate a signified of humour (albeit a morbid one), boilersuit a rare good in a genre that usually thrives on a dark, lowering position. Mortician signed with the Relapse label and debuted in 1993 with Mortal Massacre, following it with 1996's The House by the Cemetery EP and 1997's full-length, evocatively titled Hacked Up for Barbecue. Further releases included 1998's Zombi Apocalypse and 1999's Chain saw Dismemberment, which power saw producer Desmond Tolhurst beginning to contribute guitar do work as well.
Hangmen
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